Regulation of Intracerebral Pressure During Electroconvulsive Therapy. Does Systemic Bloodpressure Reflect the Intracranial Pressure?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- Rijnstate Hospital
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Pulsatility Index before, during and after electroconvulsive therapy
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to determine whether electroconvulsive therapy (ECT) has an influence on pressure within the human brain before, during and after ECT.
Detailed Description
1. Aim: 1. Our main objective concerning this study is to determine to what extent ECT does lead to an increase of the Pulsatility Index (as an indicator of intracerebral pressure) measured by a Transcranial Doppler Device (TCD). 2. As a secondary objective we want to compare the PI measurements with simultaneously measured systemic blood pressure. 2. Study design: a.Observational study: cohort study 3. Treatment: a. Treatment as usual, PI and blood pressure measurement at baseline, just before ECT, during and 5 minutes after ECT. Data will be collected during unilateral treatment during 3 consecutive ECT treatments. 4. Endpoints: 1. A minimum of sixteen patients are needed according to the power analysis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Temporal window to measure PI
- •Major depression
- •Psychotic depression
Exclusion Criteria
- •Under 18 years of age
Outcomes
Primary Outcomes
Pulsatility Index before, during and after electroconvulsive therapy
Time Frame: before, during and after three consecutive ECT treatments
Secondary Outcomes
- Bloodpressure before, during and after ECT.(before, during and after three consecutive ECT treatments.)