The Role of Sonoelastography in Evaluation of Therapeutic Response in Patients With Lymphoma.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 44
- 主要终点
- To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.
研究概览
简要总结
To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.
详细描述
Lymphomas are a heterogeneous group of malignancies that arise from the clonal proliferation of lymphocytes. It represents approximately 5% of malignancies. Overall survival is estimated to be 72%. (1)
Lymphomas are broadly classified into Hodgkin lymphoma (HL) (10%) and Non-Hodgkin lymphoma (NHL) (90%).
HL is further classified into classical and non-classical types and NHL into B-cell, T-cell and natural killer (NK) cell types. Diagnosis of lymphoma is confirmed by histopathology (FNAC, True-cut or excisional biopsy).(2) The standard treatment of lymphoma is chemotherapy and radiotherapy.
The modalities used for staging and follow up of lymphoma are:
- Computed Tomography (CT) chest, abdomen and pelvis.
- Positron Emission Tomography (PET/CT).
- Whole body Magnetic Resonance Imaging (MRI).(3)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who are histopathologically proven as lymphoma, not receive treatment and have superficial lymphadenopathy.
排除标准
- •1-Lymphoma without superficial lymph nodes. 2-patients under treatment.
结局指标
主要结局
To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.
时间窗: Average three years
Sonoelastography is a new technique that depends on the elastic properties of soft tissues, with the idea of malignant lesions being stiffer than benign or normal tissue. It may have a dependable role in evaluation of therapeutic response in patients with lymphoma and can be used for follow up, the same way it has been used in different parts of the body, such as the breast, and thyroid. To the best of our knowledge, there are few studies concerning the role of elastography in the field of lymphoma disease.
次要结局
未报告次要终点
研究者
Kerols Refaat Ayoub
Resident doctor
Assiut University