ISRCTN25571720
Completed
未知
Effect of 2 versus 3 pneumococcal conjugate vaccinations Prevnar on nasopharyngeal carriage, transmission and herd immunity; a randomized, controlled study.
niversity Medical Centre Utrecht (UMCU) (Netherlands)0 sites1,003 target enrollmentDecember 20, 2005
ConditionsInvasive pneumococcal disease, Respiratory tract infection. Added as of 22/05/2007: Change in: nasopharyngeal carriage after reduced doses 7-valent conjugate vaccine, antipneumococcal antibody development, family transmission of pneumococciInfections and InfestationsInvasive pneumococcal disease
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Invasive pneumococcal disease, Respiratory tract infection. Added as of 22/05/2007: Change in: nasopharyngeal carriage after reduced doses 7-valent conjugate vaccine, antipneumococcal antibody development, family transmission of pneumococci
- Sponsor
- niversity Medical Centre Utrecht (UMCU) (Netherlands)
- Enrollment
- 1003
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
- 2009 results in: https://www.ncbi.nlm.nih.gov/pubmed/19584345 (added 31/05/2019) 2. 2010 results in: https://www.ncbi.nlm.nih.gov/pubmed/20823436 (added 31/05/2019) 3. 2011 results in: https://www.ncbi.nlm.nih.gov/pubmed/21695210 (added 31/05/2019) 4. 2011 results in: https://www.ncbi.nlm.nih.gov/pubmed/21813135 (added 31/05/2019) 5. 2013 results in: https://www.ncbi.nlm.nih.gov/pubmed/24120678 (added 31/05/2019) 6. 2014 results in: https://www.ncbi.nlm.nih.gov/pubmed/24447437 (added 31/05/2019) 7. 2014 results in: https://www.ncbi.nlm.nih.gov/pubmed/24921688 (added 31/05/2019) 8. 2014 results in: https://www.ncbi.nlm.nih.gov/pubmed/25329446 (added 31/05/2019)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1000 healthy newborns (and family members) who will receive childhood vaccinations according to the national vaccination program, starting at 2 months of age.
Exclusion Criteria
- •Exclusion from the national vaccination program because of the presence of a medical condition requiring treatment that can interfere with the results of vaccinations, known of suspected allergy to components of the vaccine, known or suspected immunodeficiency disease other than IgA or IgG\-subclass deficiency, previous treatment with plasma or immunoglobulins, previous vaccinations other than hepatitis B vaccinations, coagulations disorders
Outcomes
Primary Outcomes
Not specified
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