Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Pilot Study
- Conditions
- Periodontitis
- Registration Number
- JPRN-UMIN000036010
- Lead Sponsor
- iigata University
- Brief Summary
ocal administration of Periocline, a minocycline slow-release formulation, was clearly effective for not only red complex bacteria but also emerging periodontopathic bacteria. However, the duration of effect was at least 4 weeks but cannot be maintained during regular SPT interval. Although the bacterial composition returned dysbiotic at 8 weeks, % sites showing BOP was remained low at 8 weeks suggesting that bacterial composition is not inflammophilic and may be different from that at baseline.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 10
Not provided
1) use of systemic or local antimicrobials in the past 6 months 2) scaling and root planing treatment under local anesthesia for target teeth in the previous 3 months 3) subgingival mechanical debridement for target teeth in the previous 1 month 4) allergies to conventional tetracycline agents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences of subgingival microbiota of test group and control group between before and after treatment
- Secondary Outcome Measures
Name Time Method 1) Change in the counts of total and red complex bacteria of subgingival plaque of test group and control group between before and after treatment 2) Change in the clinical parameters of before and after treatment between test group and control group