Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions - A Retrospective Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 319
- 试验地点
- 1
- 主要终点
- Pain reduction over time (long lasting)
研究概览
简要总结
This study is to retrospective investigate the effects of the simultaneous intravenous (i.v.) administration of lidocaine and ketamine on a four to six weeks interval in treatment refractory different chronic pain conditions.
详细描述
The use of intravenous infusion therapy with lidocaine or ketamine has been of interest in several chronic pain conditions. Studies showed a benefit in immediate pain reduction and even longer lasting pain relief for treatment approaches with lidocaine and ketamine.
While there is a broad database on the use of lidocaine and ketamine in chronic pain management as separate agents, very few pre-clinical animal studies have investigated the combined use of said analgesics and none of them reports their combined use in chronic pain patients.
This study is to retrospective investigate the effects of the simultaneous i.v. administration of lidocaine and ketamine on a four to six weeks interval in treatment refractory different chronic pain conditions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICD11 Medical diagnosis of chronic pain and its subcategories
- •Treatment with intravenous lidocaine and ketamine infusions during the years of 2012 to May 2021 at our pain unit at the USB
- •Patient is at least 18 years of age at the beginning of the first infusion treatment
排除标准
- •Patient is underage at the beginning of the first infusion treatment
- •Documented written refusal of consent for research (general consent or specific study consent)
- •Patients undergoing treatment with only lidocaine or ketamine respective
结局指标
主要结局
Pain reduction over time (long lasting)
时间窗: up to 1 year
The primary outcome (pain reduction over time) is explorative and not comparative, therefore no hypothesis is formulated and only descriptive/explorative statistics will be applied. Pain reduction will be analysed descriptively. Categories: any pain reduction/ pain reduction \>=50%/ pain free/ increase in pain (recorded as "no time stated/ \< 2 weeks/ ≥2 weeks/full time in-between infusions"
次要结局
- Change in Pain (acute reduction)(up to 1 day)