Mortality and recovery of renal function in acute kidney injury patients treated with extended dialysis
Not Applicable
Completed
- Conditions
- Acute kidney injuryUrological and Genital DiseasesAcute renal failure, unspecified
- Registration Number
- ISRCTN33774458
- Lead Sponsor
- Sao Paulo Research Foundation (FAPESP) (Brazil)
- Brief Summary
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30186631
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
1. 18 years of age or older
2. Patients with AKI associated with sepsis
3. Patients on an noradrenaline dose ranging from 0.3 to 0.7 ug/kg/min
Exclusion Criteria
1. Severe chronic kidney disease (baseline creatinine higher than 4 mg/dL)
2. Previous chronic dialysis
3. Kidney transplantation
4. Noradrenaline using a dose higher than 0.7 mg/kg/min
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. During the procedures, BP monitoring is performed every 30 min. Hypotension is defined as a single systolic BP of less than 90 mm Hg or a mean arterial pressure (MAP) of less than 60 mm Hg. To treat a hypotension episode during EDD, protocols are applied involving the infusion of saline, discontinuation of UF, and an increased dose of vasoactive drugs, according to the clinical condition and fluid status of the patient. If, despite the measures above, haemodynamic instability persisted, posing risks to the patient, the therapy are discontinued. <br>2. Filter clotting is diagnosed as the presence of blood clots in the circuit, composed of dialyser and lines, which prevented the continuation of therapy
- Secondary Outcome Measures
Name Time Method Hypokalaemia and hypophosphataemia are considered post-dialysis complications, characterised by serum levels below 3.5 mEq/l and 3.5 mg/dl, respectively