The Effect of Coenzyme Q10 Supplementation on Oxidative Stress, Inflammation and Hyperandrogenism in Women with Polycystic Ovary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- effect of coenzyme q10 administration on polycystic ovary syndrome
研究概览
简要总结
The goal of this clinical trial is to determine the effects of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome. The main questions it aims to answer are:
Does Coenzyme Q10 alter oxidative stress, inflammation and hyperandrogenism in women with Polycystic ovary syndrome.
Participants will take Coenzyme Q10 200mg, once daily for a period of 3 months. The participants will be reassessed after 12 weeks by measuring Malondialdehyde MDA, C-reactive protein CRP, Sex hormone binding globulin SHBG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Married Patients that presented with anovulatory infertility due to PCOS.
- •Unmarried Patients that presented with symptoms due to PCOS
- •All patients should fulfill Rotterdam criteria for PCOS
排除标准
- •Male factor infertility ( oligospermia or aspermia)
- •Tubal factor infertility (abnormal hysterosalpingography)
- •Diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function
- •Autoimmune and Inflammatory disorders
- •Abnormal serum prolactin level
- •Alcoholic beverage use
- •Use of anti diabetic, anti-obesity drugs, insulin or vitamin and mineral supplements
结局指标
主要结局
effect of coenzyme q10 administration on polycystic ovary syndrome
时间窗: from enrollment to the end of treatment at 12 weeks
Improvement in levels of oxidative stress , inflammatory and hyperandrogenism biomarkers in women with Polycystic ovary syndrome
The effect of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome
时间窗: from enrollment to the end of treatment at 12 weeks
Oxidative stress in PCOS is leads to imbalance in antioxidant and oxidant levels in the body, along with production of reactive oxygen species. Insulin resistance has a key role in the PCOS pathogenesis by promoting oxidative stress and promoting acute and chronic Inflammation. Studies have shown that inflammatory markers are raised in PCOS along with decreased levels of anti-inflammatory biomarkers. Coenzyme Q10 is a natural vitamin, acts as an antioxidant, have shown an constructive impact on inflammatory and endothelial dysfunction biomarkers and also effects androgen levels. Effect of Coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism will be accessed by biomarkers Malondialdehyde MDA, C-reactive protein CRP and Sex hormone binding globulin SHBG. Ideally levels of MDA, CRP would decrease and SHBG levels would increase after Coenzyme Q10 supplementation. This study would measure these three biomarkers before and after the intervention.
次要结局
未报告次要终点
研究者
hira zahid
Assistant Professor
University of Faisalabad