Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes

Not Applicable

Completed

• Conditions: Athlete
• Interventions: Dietary Supplement: Coenzyme Q10; Other: Placebo

• Registration Number: NCT03321110
• Lead Sponsor: Chung Shan Medical University

Brief Summary

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

Detailed Description

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Study Timeline

• Study First Submitted: 2017-10-13
• Study First Submitted QC: 2017-10-22
• Study First Posted: 2017-10-25
• Study Start: 2017-12-01
• Primary Completion: 2019-07-31
• Study Completion: 2019-07-31
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-19
• Last Update Posted: 2020-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• Athletes (soccer and taekwondo players)

Exclusion Criteria

• Antioxidant vitamins users
• Statins or Aspirin therapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Q10-150	Coenzyme Q10	coenzyme Q10 150 mg/d.
Q10-300	Coenzyme Q10	coenzyme Q10 300 mg/d.
Placebo	Placebo	Placebo

Primary Outcome Measures

Name	Time	Method
malondialdehyde (MDA)	12 weeks	MDA (micromol/L) will measure by thiobarbituric acid reacting substance.

Secondary Outcome Measures

Name	Time	Method
Insulin	12 weeks	insulin will measure by an automated chemistry analyzer
creatine kinase (CK)	12 weeks	serum CK will measure by enzymatic method.
one-repetition maximum (1-RM)	12 weeks	1RM measurements will report in kilograms for data analysis.
Antioxidant capacity	12 weeks	Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes.
high sensitivity C-reactive protein (hs-CRP)	12 weeks	hs-CRP will measure by immunoturbidimetry.
Glucose	12 weeks	mmol/L
Lactate dehydrogenase (LDH)	12 weeks	serum LDH will measure by enzymatic method.
HbA1C	12 weeks	HbA1C will measure by an automated glycated hemoglobin analyzer

Trial Locations

Locations (1)

Chung Shan Medical University; 🇨🇳 Taichung, Taiwan