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临床试验/NCT03321110
NCT03321110已完成不适用

Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies

Chung Shan Medical University2 个研究点 分布在 1 个国家目标入组 43 人开始时间: 2017年12月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
43
试验地点
2
主要终点
malondialdehyde (MDA)

研究概览

简要总结

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

详细描述

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Double (Participant, Care Provider)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Athletes (soccer and taekwondo players)

排除标准

  • Antioxidant vitamins users
  • Statins or Aspirin therapy.

结局指标

主要结局

malondialdehyde (MDA)

时间窗: 12 weeks

MDA (micromol/L) will measure by thiobarbituric acid reacting substance.

次要结局

  • Insulin(12 weeks)
  • creatine kinase (CK)(12 weeks)
  • one-repetition maximum (1-RM)(12 weeks)
  • Antioxidant capacity(12 weeks)
  • high sensitivity C-reactive protein (hs-CRP)(12 weeks)
  • Glucose(12 weeks)
  • Lactate dehydrogenase (LDH)(12 weeks)
  • HbA1C(12 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

LJ Hwu

Principal Investigator

Chung Shan Medical University

研究点 (2)

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