Holistic Neuropsychological Rehabilitation for Patients with Epilepsy

Phase 1

Completed

Conditions: Health Condition 1: G408- Other epilepsy and recurrent seizures

Registration Number: CTRI/2019/10/021777

Lead Sponsor: All India Institute of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 28

Inclusion Criteria

a)Age: 18-45 years

b)Education: Primary and above

c)Language: Hindi or English

d)Handedness: Both

e)Definition of DRE from according to ILEA: a failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedomâ?? (Kwan et al., 2010)

f)Age of onset: Diagnosis of epilepsy made at least in the last 1.5-2 years

g)Surgical approach: Resection for temporal or extratemporal epilepsy

h)Time since surgery: At least 3 months

i)Primary caregiver with capacity and willingness to carry out home based activities

j)Visual and auditory acuity for neuropsychological testing

k)Capacity and willingness to consent

l)Impairment in memory/attention

m)Availability of smartphone/laptop (for patients recruited after onset of COVID-19 pandemic)

Exclusion Criteria

a)IQ < 80

b)Any significant progressive disorders or unstable medical conditions requiring acute intervention

c)Hourly seizures

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Auditory Verbal Learning Test (AVLT), Everyday Memory Questionnaire (EMQ), Quality of Life in Epilepsy (QOLIE-31), Hamilton Anxiety Inventory (HAM-A), Hamilton Depression Inventory (HAM-D)Timepoint: Pre intervention, 5 months post intervention (EMQ, QOLIE-31, HAM-D, HAM-A), 6-7 months post intervention (AVLT, EMQ, QOLIE-31, HAM-A, HAM-D)

Secondary Outcome Measures

Name	Time	Method
Word Lists, Digit Span, Everyday Memory Questionnaire (EMQ), Quality of Life in Epilepsy-31 (QOLIE-31), Hamilton Anxiety Inventory (HAM-A), Hamilton Depression Inventory (HAM-D) - (For all patients recruited after onset of COVID-19 pandemic)Timepoint: Pre Intervention, 3 months post intervention