Developing Non-Communicable Disease Registries in Africa : A Step Towards Providing Quality Data for Improving Patient Outcomes
- Conditions
- Non-Communicable Disease
- Interventions
- Behavioral: Questionnaire formsOther: Bio-specimen samples
- Registration Number
- NCT03473795
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Brief Summary
This umbrella protocol seeks to develop robust data registries for non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) with the aim of providing accurate and comprehensive data for the evaluation of such diseases in sub-Saharan African countries.Healthy volunteers will be included in the study for comparison.
Additionally, the investigators aim to describe the gut microbiome community diversity of a cohort of community dwelling Nigerians and compare with CRC patients in Nigerian and at MSK. We will collect stool for microbiome and metabolomic analysis from community dwelling persons in the catchment area of ARGO facilities in Nigeria while contemporaneously administering an extensive medical and environmental exposure questionnaire.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 10000
- Age 18 and older.
- Suspected or confirmed diagnosis of a non-communicable disease. OR
- Healthy volunteers/no confirmed diagnosis for comparison.
- Participants unwilling to sign consent.
- Participants under the age of 18
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description healthy participants and participants diagnosed with NCDs Questionnaire forms This protocol will entail prospective collection of data on healthy participants and participants diagnosed with NCDs managed at collaborating institutions in SSA. Information to be obtained includes socio-demographic data, risk factors, disease-specific data, investigation and treatment details, as well as findings during follow-up. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality. Follow-up data will be updated during clinic visits and also via phone calls. healthy participants and participants diagnosed with NCDs Bio-specimen samples This protocol will entail prospective collection of data on healthy participants and participants diagnosed with NCDs managed at collaborating institutions in SSA. Information to be obtained includes socio-demographic data, risk factors, disease-specific data, investigation and treatment details, as well as findings during follow-up. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality. Follow-up data will be updated during clinic visits and also via phone calls.
- Primary Outcome Measures
Name Time Method # of patients that develope non-communicable diseases in Africa 5 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (12)
National Hospital of Abuja (Data collection only)
🇳🇬Abuja, Central Business District, Nigeria
Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC)
🇳🇬Ile-Ife, Nigeria
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Olabisis Onabanjo University Teaching Hospital
🇳🇬Sagamu, Ogun State, Nigeria
Federal Medical Centre Owo
🇳🇬Owo, Nigeria
Lagos State University Teaching Hospital
🇳🇬Ikeja, Nigeria
Ladoke Akintola University of Technology
🇳🇬Ogbomoso, Oyo, Nigeria
University of Ilorin Teaching Hospitals
🇳🇬Ilorin, Nigeria
University College Hospital
🇳🇬Ibadan, Oyo, Nigeria
University Of Nigeria Teaching Hospital (UNTH) Ituku-Ozalla Enugu
🇳🇬Enugu, Nigeria
University of Maiduguri Teaching Hospital (Data collection only)
🇳🇬Maiduguri, Nigeria
Ondo State Trauma and Surgical Centre
🇳🇬Ondo, Nigeria