Comparison of the effect of remimazolam and propofol on intraoperative neurophysiological monitoring
Not Applicable
- Conditions
- Neoplasms
- Registration Number
- KCT0006860
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Patient diagnosed with non-functioning pituitary tumor and scheduled for elective mass removal neurosurgery by transsphenoidal approach under general anesthesia. Age from 19 years to 69 years old.
Exclusion Criteria
patient with unstable vital sign, patient with neurologic deficiency, American Society of Anesthesia physical status equal or over III, Pregnant or breast feeding patient, patient with drug allergy, patient who has difficulty with communicating in Korean, Patient who disagree to participate
Drop out: Difficulty in INM monitoring after induction, INM decreases more than 50%
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method amplitude of motor evoked potential
- Secondary Outcome Measures
Name Time Method coefficient of variation of motor evoked potential;systolic/diastolic/mean blood pressure, heart rate, cardiac output, cardiac index, pulse pressure variation, stroke volume variation;dosage and target concentration of remifentanil ;frequency of hypotension and bradycardia, dosage of ephedrine, phenylephrine and atropine, Use of continuous vasopressor