EUCTR2005-001525-28-GB进行中（未招募）1 期
INFLUENCE OF THE ANTIOXIDANT N-ACETYLCYSTEINE ON INHALED NITRIC OXIDE INDUCED PULMONARY RESPONSES FOLLOWING HUMAN LUNG ISCHAEMIA-REPERFUSION INJURY
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 43
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •The expected study population will include patients undergoing lung, heart-lung and heart transplantation who meet the following inclusion criteria
- •1. The patients exhibit a moderate degree of impaired gas exchange (PaO2/FiO2 ratios within the range of 150-300 mmHg) or pulmonary hypertension (mean PAP > 25 mmHg) and increased pulmonary vascular resistance (PVR > 250 dynes x sec/cm-5) in the postoperative period
- •2. Greater than 18 years of age
- •3. signed IRB approved informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1. Severe lung injury with PaO2/FiO2 ratios < 150 mmHg in patients who are potential candidates for rescue therapy with iNO on clinical grounds
- •2. Received intravenous nitrate therapy or other investigational drug within the 24 hours preceding surgery
- •3. Pregnancy
- •4. Patients with asthma. This group will be excluded in view of potential bronchospasm as an adverse effect of N-acetylcysteine
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