NCT02594345CompletedNot Applicable
In Vitro Study of the Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation in Healthy Volunteers' Blood
Johann Wolfgang Goethe University Hospital2 sites in 1 country18 target enrollmentStarted: October 1, 2015Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 18
- Locations
- 2
- Primary Endpoint
- clotting time
Study Overview
Brief Summary
This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.
Detailed Description
The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEM®) and FACS analysis.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy volunteers
Exclusion Criteria
- •pregnancy
Outcomes
Primary Outcomes
clotting time
Time Frame: 2 months
measured by thromboelastometry (ROTEM® Analysis)
Secondary Outcomes
- clot formation(1h after exposure)
- clot stability(1h after exposure)
- clot lysis(1h after exposure)
- CD62P(3h after exposure)
Investigators
Dr Dania Fischer
Research associate
Johann Wolfgang Goethe University Hospital
Study Sites (2)
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