COMPARISON OF NEBULIZED LIGNOCAINE AND NEBULIZED KETAMINE AS AN ADJUVANT TO GENERAL ANAESTHESIA IN ATTENUATING STRESS RESPONSE TO INTUBATION AND IN REDUCING THE INCIDENCE OF POSTOPERATIVE SORE THROAT
Trial Snapshot
- Phase
- Phase 3 4
- Status
- Completed
- Sponsor
- Enrollment
- 164
- Locations
- 1
- Primary Endpoint
- To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
Study Overview
Brief Summary
A randomized clinical trial to compare the efficacy of Lignocaine(3 mg/kg) nebulisation and Ketamine nebulisation(1 mg/kg) in reducing stress response to intubation and post operative sore throat in patients requiring General Anaesthesia with endotracheal intubation. Sample size was 162 (54 in each group).
From the study we concluded that nebulization with ketamine and lignocaine are equally effective in reducing hemodynamic stress response and post operative sore throat following endotracheal intubation. There was marked rise in hemodynamic parameters and incidence of postoperative sorethroat in control group (normal saline nebulisation).
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA physical status 1 and 2 Elective surgeries Surgeries requiring General Anaesthesia with endotracheal intubation Surgeries in supine position.
Exclusion Criteria
- •Surgeries lasting for more than 4 hours Known allergy to Lignocaine or Ketamine Recent history of cough or sore throat Nasal or oral surgeries Anticipated difficult airway Pregnancy Obesity, BMI>30 Uncontrolled hypertension.
Outcomes
Primary Outcomes
To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
Time Frame: To compare the efficiency of Lignocaine airway nebulisation and Ketamine nebulisation in attenuating stress response to intubation
Secondary Outcomes
- To compare the reduction in incidence of postoperative sore throat with use of Lignocaine and Ketamine nebulisation(24 hours after surgery)