Whole Brain Vessel Wall Imaging in Stroke Patients (WISP): An International Multi-Center Registry
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 12
- 主要终点
- Vessel wall pathology findings by MRI
研究概览
简要总结
This is a new vessel wall imaging-based stroke registry which will investigate the clinical utility of the whole-brain intracranial vessel wall Magnetic Resonance Imaging (MRI) technique in assessing the etiologies in patients with ischemic stroke.
详细描述
The registry will focus on investigating the utility of whole-brain vessel wall MRI techniques in assessing the etiologies in patients with recent ischemic stroke. Patients who have had ischemic stroke (as confirmed by diffusion weighted MRI) and have had or will undergo 3D whole-brain vessel wall MRI within 8 weeks of symptom onset will be recruited into this study. It is anticipated that a total of 1000 subjects will be recruited from Feb 2017 to Feb 2019. Approximately 12 centers in the US and China will participate in the registry. MRI whole-brain vessel wall images will be analyzed for detection and characteristics of various vessel wall pathologies and association between vessel wall imaging findings and patient's clinical information.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female ≥ 18 years of age
- •Ischemic stroke onset within 8 weeks and confirmed by diffusion weighted MRI
- •Ability to read and understand informed consent
排除标准
- •The cause of stroke has been confirmed to be related to cardiac or extracranial carotid or aorta pathologies.
- •Contraindications to MR imaging including mechanically, magnetically, or electrically activated implants, ferromagnetic implants and ferromagnetic foreign bodies, pregnancy.
- •Inability to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.
- •Non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions
结局指标
主要结局
Vessel wall pathology findings by MRI
时间窗: baseline
To identify vessel wall pathologies such as atherosclerosis, dissection, vasculitis
次要结局
未报告次要终点
研究者
Zhaoyang Fan, PhD
Technical Director, 3T MRI, Biomedical Imaging Research Institute
Cedars-Sinai Medical Center