Thrombus Imaging and Treatment Analytics in Neurology
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thrombus, Brain
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Ischemic Stroke Occurrence
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.
Detailed Description
Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.
Investigators
Jinhao Lyu
Attending physician
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years
- •Extracranial and/or intracranial artery occlusion confirmed by angiography
- •Available for magnetic resonance high-resolution vessel wall imaging
- •Written informed consent obtained
Exclusion Criteria
- •Extracranial and/or intracranial artery mild to moderate stenosis
- •Pregnant women
- •Restenosis or occlusion after artery stenting placement
Outcomes
Primary Outcomes
Ischemic Stroke Occurrence
Time Frame: 1-3 Years
Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging
Rate of Successful Recanalization
Time Frame: 1-3 Years
Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.
Secondary Outcomes
- Number of Participants with Adverse Events(1-3 Years)