Measurements to Assess Severity of Epicardial Stenoses
Not Applicable
Terminated
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT00760630
- Lead Sponsor
- University of Cincinnati
- Brief Summary
Newly developed diagnostic parameters have potential to differentiate between epicardial disease and microvascular dysfunction with the help of anatomical details and physiological endpoints and can be used in present clinical settings.
- Detailed Description
The pressure drop coefficient (CDP) is a functional index based on hyperemic dp and u measurements. The lesion flow coefficient (LFC) combines the functional index CDP with an atomic measure (percentage area stenosis) as a single parameter.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Abnormal Myocardial stress perfusion (SPECT) LV EF > 25%
Exclusion Criteria
- LV < or + to 25% Serum Creatinine > 2.5 gm/dL Type II HIT Significant co-morbidities Pregnant women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method to detect ischemic heart disease in patients with abnormal stress tests using MPI with SPECT and to determine the presence of significant epicardial stenosis using coronary angiography with simultaneous physiological pressure and flow measurements Upon Diagnostic Angiogram and Flow Wire
- Secondary Outcome Measures
Name Time Method To compare novel measurements, Pressure Drop Coefficient (CDP) & Lesion Flow Coefficient (LFC), against measured current parameters called Fractional flow reserve (FFR) & Coronary flow reserve (CFR). Upon Diagnostic Angiogram and Flow Wire
Trial Locations
- Locations (2)
University Hospital
🇺🇸Cincinnati, Ohio, United States
Department of Veterans Affairs
🇺🇸Cincinnati, Ohio, United States
University Hospital🇺🇸Cincinnati, Ohio, United States