Pilot study on the effect of prophylactic versus therapeutic treatment with coal tar and vaseline lanette ointment on the skin barrier repair mechanisms in absence of a chronic inflammatory component.
- Conditions
- atopic dermatitis10014982
- Registration Number
- NL-OMON47447
- Lead Sponsor
- Dermatologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- Males and females in the age of 18-35 years;- Fitzpatrick skin type 1-3;- Caucasian race
Exclusion Criteria
- Presence of inflammatory skin disease;- Fitzpatrick skin type 4-6;- Hypersensitivity and/or intolerance to topical coal tar
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Average difference in transepidermal water loss (TEWL) and *natural<br /><br>moisturizing factors* (NMF) after prophylactic and therapeutic treatment with<br /><br>coal tar ointment or the vehicle (petrolatum) during two to four days after<br /><br>skin barrier disruption by tapestripping of the skin. </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Epidermal thickness and stratum corneum thickness due to coal tar and<br /><br>vehicle treatment<br /><br><br /><br>2. Expression of skin barrier genes and proteins due to coal tar and vehicle<br /><br>treatment<br /><br><br /><br>3. Non-invasive analysis of stratum corneum hydration due to coal tar and<br /><br>vehicle treatment<br /><br><br /><br>4. Non-invasive analysis of stratum corneum cohesion due to coal tar and<br /><br>vehicle treatment<br /><br><br /><br>5. Non-invasive analysis of corneocyte morphology due to coal tar and vehicle<br /><br>treatment<br /><br><br /><br>6. Macroscopic analysis van the tapestripped skin after coal tar and vehicle<br /><br>treatment<br /><br><br /><br>7. Non-invasive analysis of cytokines in the stratum corneum after coal tar and<br /><br>vehicle treatment.</p><br>