Time-restricted Eating and High Intensity Interval Training Among Women
- Conditions
- Obesity; Endocrine
- Interventions
- Behavioral: High Intensity Interval TrainingBehavioral: Time-Restricted Eating
- Registration Number
- NCT04019860
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
This project will determine the independent and combined effects of high intensity interval training and time-restricted eating on blood sugar regulation among women in reproductive-age who have overweight or obesity. The intervention period will be seven weeks. Before and after the intervention, blood sugar regulation, body composition and physical fitness will be measured and compared between groups who are doing either high intensity interval training, time-restricted eating, both high intensity interval training and time-restricted eating, or who are in a control group. Physical activity, sleep quality, continuous glucose monitoring, adherence to the interventions and hunger/satiety will also be measured.
- Detailed Description
In a follow-up study, we will invite randomized participants to come in for new assessments of physical fitness, body composition and fasting blood samples, and they will be asked to complete questionnaires about adherence to the interventions two years after intervention-end. The first participants will come in to the laboratory for the two-year follow up in November 2021.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 131
- body mass index ≥ 27 kg/cm2,
- able to walk on a treadmill or ride a bike for at least 60 min.
- Pregnancy, lactation within 24 weeks of study commencement
- known cardiovascular disease
- type 1 or 2 diabetes
- currently taking hypertension or glucose- or lipid-lowering medication
- habitual eating window < 12 hours
- performing high intensity training more than once a week
- body mass variations > 4 kg three months prior to study commencement
- shift work that includes night shifts.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High Intensity Interval Training High Intensity Interval Training High intensity interval training for seven weeks. Three weekly, supervised training sessions. High Intensity Interval Training & Time-Restricted Eating High Intensity Interval Training - Time-Restricted Eating Time-Restricted Eating Time-restricted eating for seven weeks. Maximal daily eating window of 10 hours. High Intensity Interval Training & Time-Restricted Eating Time-Restricted Eating -
- Primary Outcome Measures
Name Time Method Glycaemic control From baseline to after 7 weeks intervention Total area under the plasma glucose curve over two hours after a 75 g oral glucose tolerance test
- Secondary Outcome Measures
Name Time Method Body fat mass From baseline to after 7 weeks intervention In kg
Insulinemia From baseline to after 7 weeks intervention Fasting insulin in blood
24 hour glycaemic control From baseline to the last 14 days of the intervention period Average interstitial glucose levels during 24 h, area under the curve
Nocturnal glycaemic control From baseline to the last 14 days of the intervention period Average interstitial glucose levels from 23:00 h to 06:00 h
High density lipoprotein cholesterol in blood From baseline to after 7 weeks intervention Fasting high density lipoprotein cholesterol i blood
Low density lipoprotein cholesterol in blood From baseline to after 7 weeks intervention Fasting low density lipoprotein cholesterol i blood
Self-reported physical activity From baseline to after 7 weeks intervention International Physical Activity Questionnaire
Sleep From baseline to after 7 weeks intervention Self-reported: Pittsburgh Sleep Quality Index
Cardiorespiratory fitness From baseline to after 7 weeks intervention Peak oxygen uptake at a maximum effort exercise test, measured in mL/min/kg and L/min
Body mass From baseline to after 7 weeks intervention In kg
Fat-free body mass From baseline to after 7 weeks intervention In kg
Fat-free body mass percentage From baseline to after 7 weeks intervention In percent of total body mass
Diastolic blood pressure From baseline to after 7 weeks intervention Average of three measurements, in mmHg
Resting heart rate From baseline to after 7 weeks intervention Average of three measurements, in beats/min
Average glucose levels From baseline to after 7 weeks intervention Glycated haemoglobin (HbA1c)
Insulin sensitivity From baseline to after 7 weeks intervention Insulin sensitivity estimated by homeostatic model assessment for insulin resistance (fasting serum insulin concentration (μU/mL) x fasting plasma glucose levels (mmol/L)/22.5)
Insulin levels after ingestion of glucose From baseline to after 7 weeks intervention Total area under the serum insulin two hours after a 75 g oral glucose tolerance test
Body fat percentage From baseline to after 7 weeks intervention In percent of total body mass
Systolic blood pressure From baseline to after 7 weeks intervention Average of three measurements, in mmHg
Triglycerides in blood From baseline to after 7 weeks intervention Fasting low density lipoprotein cholesterol i blood
Postprandial glycaemic control From baseline to the last 14 days of the intervention period Average interstitial glucose levels 3 hours after the first meal of the day, area under the curve
Measured physical activity From baseline to the last 14 days of the intervention period Measure by Sensewear activity monitor
Cholesterol in blood From baseline to after 7 weeks intervention Total fasting cholesterol in blood
Chronotype From baseline to after 7 weeks intervention Self-reported: Hornestberg Morningness Eveningness Questionnaire
Trial Locations
- Locations (1)
Department of circulation and medical imaging , NTNU
🇳🇴Trondheim, Norway