Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study

Not Applicable

Recruiting

• Conditions: Intrabony Periodontal Defect
• Interventions: Procedure: IGF-1 Gel; Procedure: Hydroxyapatite

• Registration Number: NCT06426524
• Lead Sponsor: Dr R Viswa Chandra

Brief Summary

The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.

Detailed Description

In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed.

In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed.

Study Timeline

• Study Start: 2023-05-19
• Status Verified: 2024-05
• Primary Completion: 2024-05
• Study Completion: 2024-05
• Study First Submitted: 2024-05-17
• Study First Submitted QC: 2024-05-17
• Last Update Submitted: 2024-05-17
• Study First Posted: 2024-05-23
• Last Update Posted: 2024-05-23

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Systemically healthy male and female patients of age >18 years Intrabony defects - two wall or three wall defects Probing pocket depths (PPD) of >5mm.

Exclusion Criteria

Medically compromised patients Pregnant women Heavy smokers Patients who underwent radiotherapy or chemotherapy are excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Test group	IGF-1 Gel	In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed.
Control group	Hydroxyapatite	In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed.

Primary Outcome Measures

Name	Time	Method
Bone Regeneration	3 months and 6 months	Radiovisiography (RVG) will be used to assess bone regeneration achieved post operatively after 3 months and 6 months.
Probig depth	3 months and 6 months	Assessment of probing depth using UNC-15 probe at baseline and postoperatively at 3 and 6 months.
clinical attachment level	3 months and 6 months	Assessment of clinical attachment level using UNC-15 probe at baseline and post operatively at 3 and 6 months.

Secondary Outcome Measures

Name	Time	Method
Plaque Index	3 months and 6 months	Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index, 1970.

Trial Locations

Locations (1)

SVS Institute of Dental Sciences, Mahabubnagar; 🇮🇳 Hyderabad, Telangana, India