The effect of more radiant ventilation compared to conventional mechanical ventilation as an initial invasive respiratory intervention on reducing the duration of mechanical ventilation in preterm infants with respiratory failure

Phase 2

Recruiting

Conditions: Infants with respiratory distress syndrome with respiratory failure.
Respiratory distress syndrome of newborn
P22.0

Registration Number: IRCT20130329012869N3

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Premature infants less than or equal to 37 weeks of gestational age are admitted to the NICU
Diagnosis of Respiratory Distress Syndrome (RDS) based on clinical and radiological evidence
While supported under NCPAP, according to European consensus guideline criteria, they have been prescribed surfactant by INSURE method
Requires invasive mechanical ventilation due to respiratory failure
Intubated for the first time
Parents' consent to participate in the study

Exclusion Criteria

Intubation due to diagnosis other than Respiratory Distress Syndrome (RDS)
Under mechanical ventilation with initial embedded mode less than 12 hours
Change the infant mechanical ventilation mode from HFOV to Conventional or vice versa during treatment
Positive blood culture at birth
Existence of congenital major anomalies that affect the baby's breathing (such as severe pulmonary hypoplasia, congenital lung abnormalities, congenital airway obstruction)
Birth weight less than 600 gr
Having cyanotic heart disease
Definitive diagnosis of coronavirus (PCR positive) in mother or infant

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Days requiring mechanical ventilation. Timepoint: During the study. Method of measurement: Observation.;Duration of oxygen requirement. Timepoint: During the study. Method of measurement: Observation.;Duration of hospitalization. Timepoint: During the study. Method of measurement: Observation.

Secondary Outcome Measures

Name	Time	Method
Sepsis. Timepoint: During the study. Method of measurement: Clinical observation.;Pulmonary hemorrhage. Timepoint: During the study. Method of measurement: Clinical observation.