Tryptophan enriched diet to improve affective and cognitive functions in patients with multiple sclerosis

Phase 2

Completed

• Conditions: MS; multiple sclerosis; 10012303

• Registration Number: NL-OMON34520
• Lead Sponsor: Orbis Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 44

Inclusion Criteria

Diagnosis of multiple sclerosis

Exclusion Criteria

1) Subjects with clinically significant disease other than MS
2) Subjects who have used anti-depressive medication with 6 months before the beginning of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The Profile of Mood States (POMS) and the Positive and Negative Affect Scale<br /><br>(PANAS) are used prior, 2h and 4 h after treatment to determine changes in<br /><br>mood. Changes in plasma TRP levels and the TRP/*LNAA ratio will be determined<br /><br>over several hours after intake.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Attention processes (Trail Making Test, Affective Go/NoGo and Stroop test) and<br /><br>memory functions (affective memory test) are tested 3 h after intake. </p><br>