A randomised trial of chemotherapy with or without granulocyte colony-stimulating factor (G-CSF) in operable osteosarcoma

Not Applicable

Completed

• Conditions: Osteosarcoma; Cancer

• Registration Number: ISRCTN86294690
• Lead Sponsor: Medical Research Council (MRC) (UK)

Brief Summary

2007 Results article in http://www.ncbi.nlm.nih.gov/pubmed/17227995 results 2019 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/30879111 retrospective analysis (added 13/02/2020) 2019 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/31152023 retrospective analysis (added 28/04/2020) 2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/34916320/ retrospective analysis (added 20/12/2021) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35537786/ retrospective reanalysis (added 11/05/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2001-02-28
• Study Completion: 2002-09-30
• Last Update Posted: 23 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 497

Inclusion Criteria

1. Untreated non-metastatic disease
2. Age less than or equal to 40 years
3. Neutrophils =1.5 times 10^9/l and platelets =100 times 10^9/l
4. Glomerular Filtration Rate (GFR) =60 ml/min/1.73 m^2
5. Serum bilirubin = micromoles/L
6. Normal cardiac function
7. Informed consent

Exclusion Criteria

Not provided at time of registration

Study & Design

• Study Type: Interventional
• Study Design: Not specified