Effect of Chlorhexidine Mouthwash and Liquorice Extract Mouthrinse, on oral hygiene in Orthodontic Patients: A Comparative Study

Phase 4

Not yet recruiting

Conditions: Fixed Orthodontic Patients

Registration Number: CTRI/2025/06/089250

Lead Sponsor: Varsha Dogra

Brief Summary: Orthodontic treatment with fixed appliances increases the risk of plaque accumulation and gingival inflammation due to the difficulty in maintaining oral hygiene. This randomized, crossover clinical study compared the effectiveness of 0.12% chlorhexidine (CHX) mouthwash and 2.5% liquorice extract (LE) mouthrinse in improving periodontal health among 30 orthodontic patients. Both mouthrinses significantly reduced plaque and gingival indices, with CHX showing slightly greater efficacy. However, CHX use was associated with side effects such as tooth staining and altered taste, while LE was well tolerated with minimal adverse effects. The results suggest that 2.5% liquorice mouthrinse may serve as a viable herbal alternative to CHX in orthodontic care.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

a.Patients with good general health.
b.Patients undergoing orthodontic treatment.
c.Patients with no antibiotic intake or use of antibacterial mouthrinses in the previous 3 months, d.Patients with no periodontal disease.
e.Non-smoker, Non- alcoholic.
f.No acute oral diseases, oral infections, need for immediate periodontal care.

Exclusion Criteria

a.Any known systemic disease which effects the periodontium b.Volunteers on anti-inflammatory, antibiotics, steroids since 3 months c.Volunteers who had dental caries d.Volunteers known allergic to any product used in the study e.Non-orthodontic patients f.Patients with recent extraction g.Acute oral infection.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Herbal Liquorice Mouthwash is better and cheap alternative to Chlorhexidine Mouthwash	1 week

Secondary Outcome Measures

Name	Time	Method
Less Incidence of side effects:	-Tooth staining

Trial Locations

Locations (1): Government College of Dentistry, Indore
🇮🇳
Indore, MADHYA PRADESH, India
Government College of Dentistry, Indore
🇮🇳Indore, MADHYA PRADESH, India
Varsha Dogra
Principal investigator
09977245769
varshadogra62@gmail.com