Comparison of the effect of Metoclopramide and intravenous acetaminophen on headache in patients that presenting to the Emergency Department of Imam Khomeini hospital of Urmia

Not Applicable

• Conditions: Tension type headache; Condition 1: headache. Condition 2: headache. Condition 3: headache.; Migraine; Cluster headache syndrome

• Registration Number: IRCT2014081817812N3
• Lead Sponsor: rmia University of Medical Sciences -

Brief Summary

Introduction: Headache is the most common neurologic symptom among referees to the emergency department <br /> (ED), while the best treatment has not yet been found. Therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. Methods: This study <br /> was a double-blind randomized clinical trial performed in Imam Khomeini Hospital, Urmia, Iran, through July to <br /> October 2014. All adult patients, with acute primary (migraine, tension type and cluster) headache referred to the <br /> ED were included in this study. Pain Severity was measured with 10 centimeters numeric rating scales. The patients <br /> were randomized in to two groups of intravenous (IV) metoclopramide (10 milligrams) and acetaminophen (1<br /> gram). Pain score, success rate, and complication of drugs were compared within administration time and 15, 30, <br /> 60, as well as 120 minutes after medication. Results: 100 patients were equally categorized in to two groups (mean <br /> age of 32 ± 13.2 years; 51.2% male). Initial pain score in metoclopramide and acetaminophen groups were 9.1 and <br /> 9.4, respectively (p=0.46). IV metoclopramide did not have any analgesic effect at 15 minutes, but had good effect <br /> at 30 minutes. While, the analgesic effect of acetaminophen initiated after 15 minutes. After 2 hours, both drugs <br /> had good treatment effect on primary headaches (p

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

all 15 -75 years patients with migrane, tension and cluster headache will be enrolled in this study.
exclusion criteria: allrgy to acetaminophen and metoclopramide

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduce in headache severity. Timepoint: Q/15 minute up to 120 minute. Method of measurement: 10 numerical visual analogue scales (VAS).