NL-OMON29602尚未招募不适用
Short-course aminoglycosides as adjunctive treatment in adults with sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 3,140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1) Age >= 18 years
- •2) Presenting to the ER
- •3) Suspicion of bacterial infection of unknown origin, primary suspected urinary origin or primary suspected abdominal origin.
- •4) National Early Warning Score (NEWS) or Modified Early Warning Score (MEWS) = 5.
- •5) Requiring intravenous antibiotic treatment and hospitalization.
排除标准
- •1) Working diagnosis at the ER of pneumonia.
- •2) Chemotherapy induced neutropenia as this is considered a separate entity in the guidelines.
- •3) Pre-existing renal failure defined as a GFR < 30, due to a relative contra-indication for aminoglycosides.
- •4) Allergy for cephalosporins or aminoglycosides, known prior to the start of treatment.
- •5) Indication for empirical coverage of ESBL-producing gram-negative bacteria according to the Dutch sepsis guidelines, i.e. known colonization or infection with ESBL-producing gram-negative bacteria in the prior year.
研究者
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