NL-OMON53650招募中不适用
Short-course aminoglycosides as adjunctive treatment in adults with sepsis - SAGA
niversitair Medisch Centrum Utrecht0 个研究点目标入组 3,140 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1) Age >= 18 years
- •2) Presenting to the ER
- •3) Suspicion of bacterial infection of unknown origin, primary suspected
- •urinary origin or primary suspected abdominal origin.
- •4) National Early Warning Score (NEWS) >= 5.
- •5) Requiring intravenous antibiotic treatment and hospitalization.
排除标准
- •1) Working diagnosis at the ED of pneumonia (even if other foci are mentioned
- •in the differential diagnosis).
- •2) Chemotherapy induced neutropenia as this is considered a separate entity in
- •the guidelines.
- •3) History of renal transplantation or pre-existing renal failure defined as a
- •GFR < 30, due to a relative contra-indication for aminoglycosides.
- •4) Allergy for cephalosporins or aminoglycosides, known prior to the start of
- •antibiotic treatment.
- •5) Pre-existing hearing impairment known at the moment of presentation in the
- •6) History of heart-, lung or liver transplantation.
- •7) Known myasthenia or botulism.
- •8) A patient who has had an indwelling catheter for a prolonged period or was
- •catheterized intermittently, because of the recommended empirical treatment
- •including an aminoglycoside according to the SWAB guidelines.
- •9) Use of the medication cyclosporine, cisplatin, neuromuscular acting muscle
- •relaxants, oral neomycin and oral paromomycin due to relative contra-indication
- •for aminoglycosides.
- •10) Known colonization with a 3rd generation cephalosporin resistant bacterium
- •including Pseudomonas, relevant in the context of the infection the patient is
- •admitted with.
研究者
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