sefulness of balanced salt solution versus ringer lactate on postoperative renal parameters and arterial blood gas analysis in patients with hypertension on angiotensin receptor blockers or angiotensin converting enzyme inhibitors in surgeries under general anaesthesia
Not Applicable
- Conditions
- Health Condition 1: I10- Essential (primary) hypertensionHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/067545
- Lead Sponsor
- Dr Nishanth M
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA grade 1 and 2
Age 18-60 years
Both genders
Elective surgeries under general anaesthesia of not more than 240 mins in duration
Known case of essential hypertension since more than 2months on angiotensin convertase inhibitor or angiotensin receptor blocker medication
Exclusion Criteria
ASA grade 3and 4
Patients on diuretics
Patients on beta blockers
Patients on non-steroidal analgesics
Patients with congestive heart failure
Patients with renal artery stenosis
Patients with atherosclerosis, thrombosclerosis
Patients with excessive preoperative fluid deficit due to gastrointestinal fluid loss
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare serum potassium and eGFR in the immediate postoperative period in both the groups with baselineTimepoint: Serum potassium and eGFR within 1 hour and after 24 hours after extubation
- Secondary Outcome Measures
Name Time Method To compare perioperative urine output in both the groups.Timepoint: 24 hours urine output after extubation;To compare postoperative serum chloride levels on arterial blood gas analysis in the immediate postoperative period in both the groups With baselineTimepoint: Serum chloride levels within in 1 hour and after 24 hours of extubation;To compare serum lactate levels in the plasmalyte group with those in the Ringer’s Lactate group at different time intervals with baselineTimepoint: Serum lactate levels within 1 hour and 24 hours after extubation;To compare serum pH and standard base excess on arterial blood gas analysis in the immediate postoperative period in both the groupsTimepoint: Serum pH and standard base excess measurement at baseline, within in 1 hour and 24 hours after extubation