To compare the effect of fixed pressure versus auto adjusting continuous positive airway pressure treatments in terms of changes in heart rate and blood pressure in patients with Obstructive Sleep Apnoea

Not Applicable

Conditions: Health Condition 1: G473- Sleep apnea

Registration Number: CTRI/2022/11/047687

Lead Sponsor: Dr S Anusha Rao

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Treatment naÃ¯ve and recently diagnosed patients of age eighteen and above with moderate-severe OSA who achieve successful titration with CPAP will be included in this study.

Exclusion Criteria

1. Pregnancy

2.History of diabetes mellitus,

3.Coronary artery disease, arrhythmias, Cardiac failure,

4.Presence of other sleep disorders;

5.Central Sleep Apnea

6.Psychiatric, and neurologic disorders preventing them from being compliant to treatment;

7.Patients with craniofacial abnormalities which can hamper usage of CPAP mask.

8.Patients with prior use or using the CPAP

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure and compare the frequency domain parameters of Heart Rate Variability (LF/HF ratio, LF, HF) with reference to FP-CPAP(Fixed Pressure- Continuous Positive Airway Pressure) and APAP(Auto Positive Airway Pressure) in moderate to severe OSA(Obstructive Sleep Apnea) patients.Timepoint: At baseline, after 4weeks of initial PAP therapy, after 1 week of washout period and after 4weeks other PAP therapy <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To measure and compare time domain parameters (RMSSD,PNN50) of HRV (Heart Rate Variability) with reference to FP- CPAP and APAP in moderate to severe OSA patients. <br/ ><br>To measure and compare the autonomic function tests (Ewingâ??s battery of tests) with reference to FP-CPAP and APAP in moderate to severe OSA patients. <br/ ><br>Timepoint: At baseline, after 4weeks of initial PAP therapy , after 1 week of washout period and after 4weeks other PAP therapy