The effect of autonomic nervous system activity on the development of systemic immunosuppression and nosocomial infection in critically ill patients with brain injury

Completed

• Conditions: infection contracted in the hospital; nosocomial infection; 10004018; 10007963

• Registration Number: NL-OMON37393
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Patients with ischemic or hemorrhagic cerebrovascular accident or patients with traumatic brain injury, requiring admission and monitoring on the Intensive Care Unti or Central Medium Care

Exclusion Criteria

Moribund patients
Patients requiring an emergency thoracotomy
Known pregnancy;
Burns or inhalation injury;
Patients who received cardiopulmonary resuscitation with chest compressions (> 5 consecutive minutes) before ICU/CMC arrival
Patients with known do-not-resuscitate order prior to inclusion
Patients receiving immunosuppressive medication
Patients enrolled in a concurrent ongoing interventional, randomized clinical trial

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>nosocomial infection</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>heart rate variability, markers of sympathetic, inflammatory and coagulation<br /><br>response, 28- and 60-day mortality, ventilator-free days, length of ICU/CMC<br /><br>stay and hospital stay.</p><br>