Stimulation of the autonomic nervous system to improve postoperative recovery after colorectal surgery
Completed
- Conditions
- 10017998postoperative ileus10017977
- Registration Number
- NL-OMON32885
- Lead Sponsor
- Maaslandziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. Colorectal neoplasm selected for surgery.
2. Age > 18.
Exclusion Criteria
1 Previous gastric resection or esophagus resection
2 Disturbance of acetylcholine metabolism in neurologic disease
3 Usage of selective serotonin re-uptake inhibitors (SSRI)
4 Depression
5 Inflammatory bowel disease
6 Drugs influencing bowel motility
7 Mint allergy
8 Metastatic spreading disease
9 Stoma
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Length of hospital stay, occurrence of postoperative ileus.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Inflammatory cytokines and acute phase proteins (TNF-alpha, IL-6, CRP).<br /><br>Mediators of the inflammatory response in bowel tissue. Expression of nitric<br /><br>oxide synthases and their precursor arginine in plasma. The effect on tissue<br /><br>damage in the bowel, specified by measuring tissue damage markers in plasma and<br /><br>specifying bowel damage in the removed specimens and 24h-urine. Morbidity and<br /><br>mortality.</p><br>