Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 2
- 主要终点
- PRIMARY OUTCOME MEASURE:IMPLANTATION RATE;
研究概览
简要总结
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.
详细描述
Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF.
Patients will be randomly allotted to control and intervention group The patients in the intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior to IVF transfer cycle.
Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.
SAMPLE SIZE: 100 PATIENTS (50 in each group).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Previous failed In-vitro fertilization embryo transfer cycle
- •Patients who are good responders and have good quality embryos in the previous attempts
- •Age of patients upto 37yrs
排除标准
- •Those detected to have endometrial tuberculosis in the past, including those treated with Antituberculosis treatment
- •Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma
- •Those with sonographically detected hydrosalpinx
结局指标
主要结局
PRIMARY OUTCOME MEASURE:IMPLANTATION RATE;
时间窗: 9 MONTHS
次要结局
- CLINICAL PREGNANCY RATE,ONGOING PREGNANCY RATE(9 MONTHS)