Mild ovarian stimulation: lowest cost in vitro fertilization protocol to serve couples with difficulty to get pregnant at Hospital das Clínicas da USP

Not Applicable

Conditions: Infertility
E02.875.800, E05.820.800
C12.050.351.500

Registration Number: RBR-2xxcvqj

Lead Sponsor: Hospital das Clínicas da Universidade Federal de São Paulo

Brief Summary: There was no statistical difference between the groups for the outcomes analyzed. The control group (regular dose) had an ongoing and cumulative clinical pregnancy rate per transference of 24% and 34% and the intervention group (reduced dose) of 27% and 30% (p = 0.729 and 0.726) respectively.

Detailed Description: Not available

Recruitment & Eligibility

Status: Data analysis completed

Sex: Female

Target Recruitment: Not specified

Inclusion Criteria

women aged up to 38 years; body mass index (BMI) up to 30 kg/m²; FSH dosage less than 10 mUI/ml; antral follicle count in the initial follicular phase higher than 5 follicles

Exclusion Criteria

sperm collection performed by any method other than masturbation, such as epididymal or testicular puncture; couples who did not agree with the Informed Consent Form (TCLE)

Study & Design

Study Type: Intervention

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1: To compare the pregnancy rate per transfer and per initiated cycle in infertile couples undergoing in vitro fertilization treatment with a conventional ovarian stimulation protocol and ovarian stimulation with low doses of gonadotropins. It is expected that the study group (low-dose gonadotrophin ovarian stimulation protocol) will be non-inferior compared to the control group (conventional ovarian stimulation protocol).;Outcome found 1: In this study there was no statistical difference between the groups for clinical pregnancy rate per transfer and cumulative: control group (24% and 34%) versus minimal stimulation group (27% and 30%); p = 0.729 and 0.726) respectively.

Secondary Outcome Measures

Name	Time	Method
Expected result 2: To compare the implantation rate, miscarriage, multiples per initiated cycle in infertile couples undergoing in vitro fertilization treatment with conventional ovarian stimulation protocol and ovarian stimulation with low doses of gonadotropins. We expect to observe similar results between the study group (low-dose gonadotrophin ovarian stimulation protocol) and the control group (conventional ovarian stimulation protocol).;Outcome found 2: In this study there was no statistical difference between the groups for implantation rate, multiple pregnancy rate and miscarriage rate