Effect of Corticosteroid Injections on Blood Glucose

Suspended

• Conditions: Diabetes Mellitus; Steroid Diabetes; Knee Osteoarthritis; Hip Osteoarthritis; Shoulder Osteoarthritis; Adhesive Capsulitis

• Registration Number: NCT05048264
• Lead Sponsor: Duke University

Brief Summary

The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.

Detailed Description

The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee, and hip joints in diabetic patients on resultant blood glucose readings.

Corticosteroid injections (CSI) are frequently used in orthopedic settings in order to treat a wide array of orthopedic issues, including osteoarthritis, bursitis, tendinitis, and many others. The effect of diabetes on the musculoskeletal system and its role in orthopedic disease has been well-documented. Current evidence demonstrates that corticosteroids, even when administered through a local musculoskeletal injection, can lead to temporary increases in blood glucose. Ultrasound guidance was not explicitly used in any of the studies examining the impact of steroids on blood glucose. The utilization of ultrasound guidance has been shown to increase accuracy when performing injections into the subacromial space as well as the glenohumeral joint when compared to palpation/landmark-guided injections.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-09-08
• Study First Submitted QC: 2021-09-16
• Study First Posted: 2021-09-17
• Study Start: 2023-05-04
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-13
• Last Update Posted: 2024-11-15
• Primary Completion: 2025-10-11
• Study Completion: 2025-10-25

Recruitment & Eligibility

• Status: SUSPENDED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Known diabetic patients ages 40-75 undergoing clinically indicated standard of care corticosteroid shoulder, knee and hip joint injection
• Ability to perform daily blood glucose testing
• Can receive and send text messages

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Exclusion Criteria

• Previous joint arthroplasty
• Corticosteroid injection at other sites in the body within the past month
• Systemic corticosteroid within the last month other than asthma inhaler
• Anyone who are unable to read and/or understand English
• Pregnant women (self-report)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in blood glucose measures	Baseline & 2 weeks	Reported daily glucose measures from baseline to two week after injection

Trial Locations

Locations (1)

Duke Sports Science Institute; 🇺🇸 Durham, North Carolina, United States