Evaluation the effect of Trans Sodium Crocetinate(TSC) on re perfusion Injury in Acute Myocardial Infarctio

Phase 3

Recruiting

Conditions: STEMI.
ST elevation (STEMI) myocardial infarction of unspecified site
I21.3

Registration Number: IRCT20120520009801N5

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients should be between 18 and 76 years old
Patients with myocardial infarction with an ascending ST segment
Meet the entry requirements under the AHA2019 guideline
Candidates for PPCI
Zero TIMI score at admission

Exclusion Criteria

Be pregnant or breastfeeding
History of allergy to formulations used in the study.•
The patient enters another similar plan and receives other drugs that affect treatment response in the past month
The person has cardiogenic shock and is forced to use pressure therapy
The patient has IABP
History of acute myocardial infarction
GFR less than 60 ml / min•
Patients with cardiac arrest
Patient with VF
Patient with hepatic impairment AST / ALT> 5ULN
Patient with a history of chronic inflammatory disease
Patient with LMCA involvement
Patient with a history of myocardial infarction or ACS within 4 hours before the current episode

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative amounts of Troponin I Tn I enzyme and drawing the shape of the Tn I time concentration curve. Timepoint: At zero time, 6, 12 and 24 hours after PPCI. Method of measurement: High-Sensitivity Troponin Test-Laboratory.

Secondary Outcome Measures

Name	Time	Method
Evaluation of the patient's electrocardiogram and recording of ventricular and supraventricular arrhythmias, number of PVCs, PR / QT / QRS intervals, and evaluation of the cumulative amount of ST segment (STR Percentage). Timepoint: Daily until discharge. Method of measurement: Through ECG examination.;Ejection fraction and evaluation of systolic and diastolic status of all 4 chambers of the heart and LV ENLARGMENT. Timepoint: Daily until discharge. Method of measurement: Echocardiography.;Evaluation of biochemical parameters INR, BUN, Scr Na, K, Ca, Mg, ALT, AST. Timepoint: Daily until discharge. Method of measurement: Laboratory.;Evaluation of the balance between oxidants - antioxidants. Timepoint: Two samples at time zero and patient discharge time. Method of measurement: Laboratory.