Evaluation of the effect of crocin in the treatment of cystoid macular edema secondary to retinitis pigmentosa

Phase 2

Recruiting

Conditions: Retinitis pigmentosa.
Hereditary retinal dystrophy
H35.5

Registration Number: IRCT20201219049753N2

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Patients with typical retinitis pigmentosa with increased central macular thickness
They have not received treatment for this condition in the last 3 months
They have the ability to understand the study and the power to choose to participate in the study.

Exclusion Criteria

History of diabetes
Recent ocular surgery
pregnancy and lactation period
History of taking drugs that cause macular edema in the last 3 months
Suffering from other eye diseases that lead to macular cystoid edema

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The CMT in OCT. Timepoint: The central thickness of the macula in OCT at the beginning of the study before the intervention and at the end of the first, second and third month. Method of measurement: Macular OCT.;Size of cysts in the macula oct. Timepoint: At the beginning of the study before the intervention and at the end of the first, second and third month. Method of measurement: macula oct.

Secondary Outcome Measures

Name	Time	Method
Best corrected visual acuity (BCVA). Timepoint: Best corrected visual acuity (BCVA) at the beginning of the study before the intervention and at the end of the first, second and third month. Method of measurement: Optometry.;Liver function tests. Timepoint: before the intervention and at the end of the study. Method of measurement: chemistry analyzer.;Kidney function tests. Timepoint: before the intervention and at the end of the study. Method of measurement: chemistry analyzer.;Fasting blood lipid profile. Timepoint: before the intervention and at the end of the study. Method of measurement: chemistry analyzer.;Fasting blood sugar. Timepoint: before the intervention and at the end of the study. Method of measurement: chemistry analyzer.;Complete blood count. Timepoint: before the intervention and at the end of the study. Method of measurement: hematology analyzer.