Assessment of Autonomic Dysfunction in Parkinsons Disease by Heart Rate Variability: An Analytical Cross-Sectional Study

HBT Medical College Dr RN Cooper Hospital Mumbai0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年5月29日

试验速览

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•Heart rate variability to assess autonomic functions will be studied in 65 consecutive
•patients presenting with idiopathic PD according to the MDS-PD criteria, age 30-60
•years visiting neurology outpatient department of Municipal General Hospital. Prior
•approval of ethics committee will be taken and informed consent obtained from the
•patients. Patients without any concomitant cardiovascular disease as confirmed by physical examination and normal 12-lead ECG will be included in the study.

•Patients suspected of atypical/ secondary Parkinsonism as per MDS-PD criteria will be excluded from the study. Patients with dementia (as assessed by Mini Mental
•State Scale) that would affect their ability to provide consent and reliable self
•report will be excluded from the study. Patients with other medical conditions or co-morbidities or drugs as assessed by history, clinical examination and previous investigations known to affect autonomic nervous system or heart rate variability will be excluded from the study.
•1. Atypical/ secondary Parkinsonism
•2. Significant neurological disease such as stroke or epilepsy
•3. Diabetes mellitus
•4. Coronary artery disease / heart failure / myocardial infarction
•4. Dyslipidemia, Hypertension
•5. History of smoking/ alcohol intake
•6. Broncho- pulmonary disease, dypnea.
•7. Amyloidosis/ neuropathy
•8.Patients who had medication known to influence autonomic system and biological rhythms will also be excluded from the study.

发起方

HBT Medical College Dr RN Cooper Hospital Mumbai