Tramadol versus Naproxen for Pain Relieving in Knee Osteoarthritis: a pragmatic randomized controlled trial

Khon Kaen hospital0 个研究点目标入组 40 人开始时间: 2018年2月16日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Eligible patients were 20 years of age or older with a diagnosis of unilateral primary or secondary osteoarthritis of the knee defined by the American College of Rheumatology criteria.

•Patients were excluded if they had used of analgesic e.g., acetaminophen, topical NSAIDs, and topical methyl salicylate or anti-inflamma drugs including NSAIDs and corticosteroids within one week before recruitment, diagnosed with rheumatoid arthritis, fibromyalgia, ankylosing spondylitis, active gout, pseudogout, or other inflammatory disorder, inflammatory or post-infectious arthritis, previous major knee trauma (knee fracture, knee subluxation/dislocation, neurovascular injury), previous arthroscopic treatment or total knee replacement, previous drug allergy or intolerance for opioid or NSAIDs, history of ASCVD (stroke, coronary heart disease) or high risk for ASCVD, history of drug or alcohol abuse, history of peptic ulcer disease, from patient or recorded in the patient card, hepatic or renal impairment (AST or ALT above normal range, GFR below 30 ml/min/1.73 m2), diagnosis of severe persistent asthma or COPD (uncontrolled symptom with exacerbate everyday), platelet <100,000 mm3, pregnancy or breast feeding (by LMP).

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