NCT01930279Unknown不适用
Effect of Sleep Deprivation on Expression of T Cell Markers in Peripheral Blood of Medical Residents
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- surface markers of T cell as assessed by FACS
研究概览
简要总结
Sleep deprivation was found to affect many organs including the immune system and predisposing for various health consequences including diabetes hypertension infections and increase in neoplastic diseases.
Subjects will be evaluated for immune parameters in peripheral blood test following a regular nigh sleep and compared with a test performed following a night shift in which they slept less than 3 hours.
Each participant will serve as its own control.
详细描述
Overall Study Design and Plan
- Subjects will be bled on the day of the experiment between 8and 9 AM.
- Blood tubes will be tested for T cell markers, serum cytokines levels, and other immune parameters by western blots.
- The first tube will be tested on the day of experiment.
- The second tube will kept in the lab and will be tested 24 hours later.
- The third tube will be kept in the pocket of the subject and be tested 24 hours later.
- The fourth tube will be kept in the pocket of another subject and will be tested 24 hours later.
- The subject will be tested again following 24 hours.
- Each subject will be tested twice following a regular 6-8 hours of sleep, and following an on call duty in which he slept less than 3 hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female ages 18-40 signed confirmed consent no evidence of chronic disease or chronic medications
排除标准
- •Any type of acute infection or other acute illness
结局指标
主要结局
surface markers of T cell as assessed by FACS
时间窗: 6 months
serum cytokine levels
时间窗: 6 months
immune parameters to be assessed by western including STAT proteins
时间窗: 6 months
次要结局
未报告次要终点
研究者
ayman abu rmaileh
MD
Hadassah Medical Organization
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care UnitSleep DeprivationNCT01082016University of Arizona75
招募中
不适用
Immune Status After Being on Call for 24 HrsSleep DeprivationNCT06636318University of Chicago60
招募中
不适用
Impact of Sleep Disorders on Innate Immunity in COVID-19 PatientsApnea, Obstructive SleepSARS CoV 2 InfectionNCT06341374Parc Taulí Hospital Universitari50
尚未招募
不适用
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal VolumeSleep DeprivationHippocampal AtrophyCortical IrregularityNCT06260280Instituto Mexicano del Seguro Social37
已完成
不适用
The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on MetabolismSleep DeprivationSleepNCT01800253Uppsala University17