Evaluation of Perfusion and Oxygenation in Muscle of Patients With PAD Undergoing LER
- Conditions
- Peripheral Arterial Disease
- Registration Number
- NCT06645353
- Lead Sponsor
- Medical University of Graz
- Brief Summary
During this IIT, the MSOT (Multispectral Optoacoustic Tomography ) Acuity Echo will be used to scan participants with Peripheral Arterial Disease assess MSOT Multispectral Optoacoustic Tomography (single-wavelength and hemoglobin-related parameters) in the Tibialis Anterior, and flexor hallucis brevis, at multiple time-points before, during and after interventional Lower Extremity Revascularization (LER ).
Primary aim of the study ist the Comparison of the difference between oxygenated, deoxygenated hemoglobin and oxygenation in the tibialis anterior, and flexor hallucis brevis, at multiple time-points before, during and after interventional Lower Extremity Revascularization.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 55
-
• Written consent of the participant after being informed
- Adults above 18 years
- Participants with PAD stage 4 - 6 (Rutherford) with indication for interventional LER
-
• Participants with previous LER on the same leg
- Participants less than 18years
- Pregnancy
- Participants with tattoos in the scan area
- Participants with no clinical indication for interventional LER
- Missing consent form
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MSOT Multispectral Optoacoustic Tomography, baseline pre LER, 30 minutes post LER, 24 hours post LER, 48hours post LER single-wavelength, HbT, Hb, HbO2, collagen and mSO2 (700-1.100 nm wavelength range, in 10 nm increments) in the tibialis anterior and flexor hallucis brevis, at multiple time-points before, during and after interventional LER Lower Extremity Revascularization .
- Secondary Outcome Measures
Name Time Method