Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Nutrients on Liver Fat Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Dietary fatty acid partitioning
研究概览
简要总结
There is a largely unsubstantiated thought in the literature that dietary unsaturated enter oxidation pathways preferentially compared to saturated fatty acids. This study is undertaking a direct comparison of the oxidation of dietary saturated and unsaturated fatty acids.
详细描述
Provided subjects meet the inclusion criteria, then at least one week after the screening visit volunteers will then undertake the first two 'study days'. There will be two study days on separate occasions that will be up to 3 weeks apart. Each study day will be approximately 7 hours in duration. On each study day participants will be given a standardised 'test' meal that contains specially labelled fat molecules (stable-isotope tracer) and then repeated breath and blood samples will be taken over the course of the next 6 hours. The test meal consumed on each 'study day' will be identical in composition with only the specially labelled fat molecules being different (either unsaturated or saturated fat) and these will be given in a random order.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is willing and able to give informed consent for participation in the study.
- •Male or Female, aged >18 and <65 years BMI >19 <35kg/m2 No medical condition or relevant drug therapy known to affect liver metabolism
排除标准
- •• Age <18 or >65 years
- •Body mass index <19 or >35kg/m2
- •A blood haemoglobin <120mg/dL
- •Any metabolic condition or relevant drug therapy
- •History of alcoholism or a greater than recommended alcohol intake
- •Pregnant or nursing mothers
- •Women prescribed hormone replacement therapy (HRT) or who have used this within the last 12 months
- •History of severe claustrophobia
- •Presence of metallic implants, pacemaker
- •Haemorrhagic disorders
- •Anticoagulant treatment
结局指标
主要结局
Dietary fatty acid partitioning
时间窗: 6 hours
The appearance of the 13Clabelled fatty acid in plasma triglycerides
次要结局
未报告次要终点