Dexmedetomidine vs ketamine to reduce analgesia requirement in opioid addicts

Phase 2

Conditions: opioids abuse.
Mental and behavioural disorders due to use of opioids

Registration Number: IRCT201307203436N3

Lead Sponsor: Anesthesiology Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Science

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 100

Inclusion Criteria

Inclusion:
1- ASA physical status I or II
2- No probability for difficult airway
3- No allergy to remifentanil, ketamine, propofol or dexmedetomidine
4- No alcohol, tranquilizer or intravenous drug abuse
5- No cognitive or memory disorder
6- No history for hypertension, Increased ICP, present pregnancy or psychiatry disorder
Exclusion:
1- surgery lasts more than 4 hours
2- Mean arterial pressure (MAP) change greater than 30 % lasting more than 5 minutes
3- Pulse rate change greater than 30% lasting more than 5 minutes
4- Application of drugs not mentioned in the protocol (however data is recorded)

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post operative morphine requirement. Timepoint: (post intervention) 24 h postoperative. Method of measurement: mg.;Intra-operative remifentanil requirement. Timepoint: (during and post intervention) during surgery. Method of measurement: micrigram.

Secondary Outcome Measures

Name	Time	Method
Bradypnea (RR less than 8/min). Timepoint: (after intervention) recovery. Method of measurement: pulse oximetry.;Apnea (central apnea for more than 10 sec). Timepoint: (after intervention) recovery. Method of measurement: Observation.;Itching (post-operative complaint of patient). Timepoint: (after intervention) recovery and 24 h post-operatively. Method of measurement: Observation.;Recovery discharge time. Timepoint: (after intervention) recovery. Method of measurement: minutes from arrival to discharge.;Hemodynamic instability. Timepoint: (during and after intervention) under anesthesia. Method of measurement: blood pressure and heart rate every 5 minutes (recording).