ow-dose intravenous ketamine with haloperidol in reducing delirium and agitatio

Phase 3

• Conditions: Condition 1: Delirium in elderly patients. Condition 2: Agitation in elderly patients.; Delirium, not induced by alcohol and other psychoactive substances; R45.1; Restlessness and agitation

• Registration Number: IRCT20230522058252N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 25 July 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

Age over 65 years and hospitalization in the intensive care unit
Richmond Agitation Sedation Score more equal to 2
Troponin and BNP not positive
Systolic pressure less than 140 mm Hg
Diastolic pressure less than 95
Heart rate less than 100

Exclusion Criteria

Dissatisfaction of the patient or the patient's guardian
Cardiovascular disease
History of psychosis

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reynolds and Richmond score less than one. Timepoint: At the beginning of the study (before the injection) and again at 5, 10, 15 minutes after the injection. Method of measurement: Reynolds and Richmond Score.

Secondary Outcome Measures

Name	Time	Method
The duration of reaching a Reynolds and Richmond score less than one. Timepoint: At the beginning of the study (before the injection) and again at 5, 10, 15 minutes after the injection. Method of measurement: Reynolds and Richmond Score.;Side effects. Timepoint: 60 minutes after the start of the intervention. Method of measurement: ECG to evaluate QT interval, blood pressure, heart rate, presence of seizures or hallucinations before and after receiving any of the drugs.