Cortisol as marker to assess stress response in Traumatic Brain Injury patients.
Phase 1
- Conditions
- Health Condition 1: V229- Unspecified motorcycle rider injured in collision with two- or three-wheeled motor vehicle in traffic accident
- Registration Number
- CTRI/2019/11/022121
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients of 18years and above with GCS of 8 or less with an isolated head injury on ct finding requiring mechanical ventilation for more than 48hrs.
Exclusion Criteria
1. refusal to give consent.
2.an elapsed time between trauma and icu admission of more than 24hrs.
3.gcs of 3 persistant from the scene with bilaterally dilated fixed pupils.
4.patients undergoing operation
5.patients on haemodynamic support.
6.patients whose baseline serum cortisol level is less than 15mg/dl
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TO access if intravenous Propofol provides better obtundation of stress response due to traumatic brain injury as compared to Midazolam infusion when measured by change in serum cortisol levelsTimepoint: 3months follow up on 21/12/2019
- Secondary Outcome Measures
Name Time Method 1.To assess hemodynamic changes <br/ ><br>2.To assess GCS, ONSD <br/ ><br>3.To assess GOS <br/ ><br>4.TO find out fentanyl requirement <br/ ><br>5.To recored complication <br/ ><br>6.To record additional therapyTimepoint: 48hrs after sedation