Calcium-protein Co-ingestion and Gut Hormones

Not Applicable

Completed

• Conditions: Obesity; Diabetes
• Interventions: Dietary Supplement: Milk Mineral Supplement; Dietary Supplement: Whey Protein Hydrolysate

• Registration Number: NCT03370497
• Lead Sponsor: University of Bath

Brief Summary

Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may potentiate the effects of protein ingestion on gut hormone secretion. Evidence in humans however, is lacking. This study aims to assess whether the addition of calcium to protein ingestion augments postprandial gut hormone availability in humans.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2017-12-06
• Study First Submitted QC: 2017-12-11
• Study First Posted: 2017-12-12
• Primary Completion: 2018-01-31
• Study Completion: 2018-02-28
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-26
• Last Update Posted: 2018-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Healthy men and women age between 18-65 yrs.
• Able to consume provided supplement.
• Weight stable for the past 3 month (no change within 3%)

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Exclusion Criteria

• Any previous or current metabolic, cardio-pulmonary or musculoskeletal disease
• Not between the ages of 18-65 years
• A body mass index below 18.5 kg/m2 or above 30 kg/m2 (body mass (kg) divided by your height (m) squared)
• Taking medications that may influence your metabolism
• Plans to change your lifestyle (diet and/or physical activity) during the study period
• Not willing to refrain from alcohol containing drinks or unaccustomed exercise one day before the laboratory sessions.
• Current smoker

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Whey protein hydrolysate plus milk mineral supplement	Milk Mineral Supplement	Milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion.
Whey protein hydrolysate plus milk mineral supplement	Whey Protein Hydrolysate	Milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion.
Whey protein hydrolysate	Whey Protein Hydrolysate	Whey protein hydrolysate (50 g) will be consumed by participants in the morning between 8-10 am after 8-14 h fasting. Blood samples, appetite scales and expired breath samples will be taken in a regular intervals for 2 h after ingestion.

Primary Outcome Measures

Name	Time	Method
Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).	120 min	Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).

Secondary Outcome Measures

Name	Time	Method
Postprandial plasma GIP area under the curve (mmol/L x 120 min)	120 min	Postprandial plasma GIP area under the curve (mmol/L x 120 min)
Subjective ratings of appetite (au)	120 min	Subjective ratings of appetite (au)
Postprandial plasma PYY area under the curve (mmol/L x 120 min)	120 min	Postprandial plasma PYY area under the curve (mmol/L x 120 min)

Trial Locations

Locations (1)

Department for Health, University of Bath; 🇬🇧 Bath, United Kingdom