Calcium and Gut Hormones

Not Applicable

Completed

• Conditions: Obesity; Diabetes
• Interventions: Dietary Supplement: Milk mineral supplement; Dietary Supplement: Control

• Registration Number: NCT03370484
• Lead Sponsor: University of Bath

Brief Summary

Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may stimulate gut hormone secretion. Evidence in humans however, is lacking. This study aims to assess whether the calcium ingestion stimulates gut hormone availability in humans.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2017-12-06
• Study First Submitted QC: 2017-12-11
• Study First Posted: 2017-12-12
• Primary Completion: 2018-01-31
• Study Completion: 2018-02-28
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-26
• Last Update Posted: 2018-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Healthy men and women age between 18-65 yrs.
• Able to consume provided supplement.
• Weight stable for the past 3 month (no change within 3%)

Read More

Exclusion Criteria

• Any previous or current metabolic, cardio-pulmonary or musculoskeletal disease
• Not between the ages of 18-65 years
• A body mass index below 18.5 kg/m2 or above 30 kg/m2 (body mass (kg) divided by your height (m) squared)
• Taking medications that may influence your metabolism
• Plans to change your lifestyle (diet and/or physical activity) during the study period
• Not willing to refrain from alcohol containing drinks or unaccustomed exercise one day before the laboratory sessions.
• Current smoker

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Milk mineral supplement	Milk mineral supplement	Milk Minerals containing 1000 mg calcium with artificial sweetener and water
Control	Control	Water with artificial sweetener

Primary Outcome Measures

Name	Time	Method
Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).	120 min	Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).

Secondary Outcome Measures

Name	Time	Method
Postprandial plasma PYY area under the curve (mmol/L x 120 min)	120 min	Postprandial plasma PYY area under the curve (mmol/L x 120 min)
Postprandial plasma GIP area under the curve (mmol/L x 120 min)	120 min	Postprandial plasma GIP area under the curve (mmol/L x 120 min)
Subjective ratings of appetite (au)	120 min	Subjective ratings of appetite (au)

Trial Locations

Locations (1)

Department for Health, University of Bath; 🇬🇧 Bath, United Kingdom