NCT03370484已完成不适用
The Effect of Calcium Ingestion on Gut Hormone Secretion.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).
研究概览
简要总结
Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may stimulate gut hormone secretion. Evidence in humans however, is lacking. This study aims to assess whether the calcium ingestion stimulates gut hormone availability in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women age between 18-65 yrs.
- •Able to consume provided supplement.
- •Weight stable for the past 3 month (no change within 3%)
排除标准
- •Any previous or current metabolic, cardio-pulmonary or musculoskeletal disease
- •Not between the ages of 18-65 years
- •A body mass index below 18.5 kg/m2 or above 30 kg/m2 (body mass (kg) divided by your height (m) squared)
- •Taking medications that may influence your metabolism
- •Plans to change your lifestyle (diet and/or physical activity) during the study period
- •Not willing to refrain from alcohol containing drinks or unaccustomed exercise one day before the laboratory sessions.
- •Current smoker
研究组 & 干预措施
Control
Placebo Comparator
Water with artificial sweetener
干预措施: Control (Dietary Supplement)
Milk mineral supplement
Experimental
Milk Minerals containing 1000 mg calcium with artificial sweetener and water
干预措施: Milk mineral supplement (Dietary Supplement)
结局指标
主要结局
Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).
时间窗: 120 min
Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min).
次要结局
- Postprandial plasma GIP area under the curve (mmol/L x 120 min)(120 min)
- Subjective ratings of appetite (au)(120 min)
- Postprandial plasma PYY area under the curve (mmol/L x 120 min)(120 min)
研究者
Javier Gonzalez
Associate Professor
University of Bath
研究点 (2)
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