The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction

Not Applicable

Completed

• Conditions: Endothelial Dysfunction
• Interventions: Other: Control Condition; Other: Exercise Condition

• Registration Number: NCT02919488
• Lead Sponsor: Texas Christian University

Brief Summary

The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise

Detailed Description

Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting substances produced by the endothelium. An imbalance in these substances limits the ability of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction is a major risk factor for cardiovascular disease.

High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two studies that have examined the effect of exercise on endothelial dysfunction induced by high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired flow mediated dilation induced by high-sugar ingestion. Neither study measured important markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin II concentrations, however. In addition, whether the same results apply to older post-menopausal women is unknown. Understanding how acute exercise affects meal-induced endothelial dysfunction in older women is important given that age is related to endothelial dysfunction and cardiovascular disease.

Study Timeline

• Study First Submitted: 2016-09-27
• Study First Submitted QC: 2016-09-28
• Study First Posted: 2016-09-29
• Study Start: 2016-11
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-25
• Last Update Posted: 2018-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 22

Inclusion Criteria

• Post-menopausal women
• Must be 45-70 years

Exclusion Criteria

• Use of medications or supplements to lose weight
• Following a weight loss diet
• Smoking
• Heavy alcohol consumption
• Diabetes
• Heart disease
• Stroke
• Liver disease
• Kidney disease
• Untreated thyroid disease
• Anemia
• Uncontrolled hypertension
• Pulmonary disease that prevents exercise
• Orthopedic problems that prevents exercise
• Arthritis problems that prevent exercise
• Musculoskeletal problems that prevent exercise.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control Condition	Control Condition	-
Exercise Condition	Exercise Condition	-

Primary Outcome Measures

Name	Time	Method
Change in brachial artery flow mediated dilation	0, 60, 120, and 180 minutes

Secondary Outcome Measures

Name	Time	Method
Change in blood nitric oxide concentration	0, 60, 120, and 180 minutes
Change in blood angiotensin II concentration	0, 60, 120, and 180 minutes
Change in blood glucose concentration	0, 60, 120, and 180 minutes
Change in blood endothelin-1concentration	0, 60, 120, and 180 minutes
Change in blood insulin concentration	0, 60, 120, and 180 minutes
Change in blood lipoprotein particle numbers	0, 60, 120, and 180 minutes
Change in blood lipid concentration	0, 60, 120, and 180 minutes

Trial Locations

Locations (1)

Texas Christian University; 🇺🇸 Fort Worth, Texas, United States