The effects of glutamine supplementation in type 2 diabetes
Not Applicable
- Conditions
- Diabetes mellitus.Non-insulin dependent diabetes mellitus
- Registration Number
- IRCT201205279373N1
- Lead Sponsor
- Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patient diagnosed with type 2 diabetes based on ADA definition or who only take oral antidiabetic drug
Exclusion criteria: history of drug dependence; body mass index (BMI) =35 kg/m2; history of cancer; treatment with anti-inflammatory; corticosteroid; hormonal or antibiotic agents; a restrictive diet or weight change = 5 kg during the 3months prior to study; systolic blood pressure >160 mmHg and/or diastolic blood pressure > 90 mmHg; fatty liver disease; liver or kidney disease; autoimmune disease; pregnancy and lactation; any change in treatment with oral hypoglycemic; anti hypertensive and antilipid agents during the study; use of weight loss medications; HbA1C >8
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fast blood sugar. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl / enzymatic.;GLP-1 ( Glucagon- like peptide-1). Timepoint: Before and 6 weekes after the intervention. Method of measurement: pmol/ l / ELISA.;Serum insulin. Timepoint: Before and 6 weekes after the intervention. Method of measurement: pmol/ l / IRMA method.;Serum c peptide. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ l.;Hs- CRP. Timepoint: Before and 6 weekes after the intervention. Method of measurement: ELSA.;Resting energy expenditure. Timepoint: Before and 6 weekes after the intervention. Method of measurement: indirect calorimetry.
- Secondary Outcome Measures
Name Time Method Srum glutamine. Timepoint: Before and 6 weekes after the intervention. Method of measurement: spectrophotometric.;Blood pressure. Timepoint: Before and 6 weekes after the intervention. Method of measurement: blood pressure,sphygmomanometer.;Total cholestrol. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl.;HDL-C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/ dl.;LDL-C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl.;Hb A1C. Timepoint: Before and 6 weekes after the intervention. Method of measurement: fast HbA1c serum level,Chromatography.;Serum creatinine. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl.;Body composition. Timepoint: Before and 6 weekes after the intervention. Method of measurement: Tanita body composition analyzer.;Triglyceride. Timepoint: Before and 6 weekes after the intervention. Method of measurement: mg/dl.