1-1-12 Wash-in for Desflurane Low Flow Anesthesia

Completed

• Conditions: Anesthesia
• Interventions: Procedure: 1-1-12 wash-in

• Registration Number: NCT02013882
• Lead Sponsor: Khon Kaen University

Brief Summary

We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.

Detailed Description

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Study Timeline

• Study First Submitted: 2013-12-05
• Study First Submitted QC: 2013-12-11
• Study First Posted: 2013-12-17
• Study Start: 2014-01
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2014-02
• Last Update Submitted: 2014-02-08
• Last Update Posted: 2014-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• ASA classification I-II
• age 18-64 years

Exclusion Criteria

• BMI > 35
• contraindicated for N2O
• with pulmonary or cardiac disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1-1-12 wash-in	1-1-12 wash-in	wash-in using O2:N2O 1:1 L/min with desflurane 12%

Primary Outcome Measures

Name	Time	Method
Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%	participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes

Secondary Outcome Measures

Name	Time	Method
Heart rate	participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes

Trial Locations

Locations (1)

Srinagarind Hospital; 🇹🇭 Khon Kaen, Thailand