1-1-12 Wash-in for Desflurane Low Flow Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%
研究概览
简要总结
We propose a new wash-in technique for desflurane low flow anesthesia with fresh gas flow of O2:N2O 1:1 L/min with desfluraene 12%.
The objective of this study is to identify time to achieve alveolar concentration of desflurane at1, 2, 3, 4, 5 and 6%.
详细描述
The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols are complicated and time consuming. We propose a new 1-1-12 desflurane wash-in protocol which is more simple and predictable.
The objective of this study is to identify time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% with 1-1-12 wash-in protocol.
All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O 1:1 L/min with desflurane 12%. Time to achieve alveolar concentration of desflurane at 1, 2, 3, 4, 5 and 6% will be recorded and analyzed. After that, the concentration of desflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA classification I-II
- •age 18-64 years
排除标准
- •BMI > 35
- •contraindicated for N2O
- •with pulmonary or cardiac disease
结局指标
主要结局
Time (in second) to achieve alveolar concentration of desflurane 1, 2, 3, 4, 5 and 6%
时间窗: participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes
次要结局
- Heart rate(participants will be followed until alveolar concentration of desflurane reaches 6%, as expected of 15 minutes)
研究者
Thepakorn Sathitkarnmanee
Associate Professor
Khon Kaen University