BFR Training on Muscle Morphology

Not Applicable

Recruiting

• Conditions: Blood Flow Restriction Training; Eccentric Training; Muscle Morphology; Anterior Cruciate Ligament Injuries; Patellofemoral Pain Syndrome
• Interventions: Procedure: Sham Low load-BFRt; Procedure: High load-Eccentric training; Procedure: Low load-BFRt

• Registration Number: NCT06566950
• Lead Sponsor: Udayana University

Brief Summary

This randomized clinical trial study compares high-load eccentric training (HL-Et), sham LL-BFRt, and low-load blood flow restriction (LL-BFRt) in sportsmen. The primary inquiries it seeks to address are:

Is LL-BFR superior to HL-Et and sham LL-BFRt in terms of improving muscle morphology? Is LL-BFR a more effective Patellofemoral Pain Syndrome and ACL injury preventive than HL-Et and sham LL-BFRt?

The three intervention groups that will be randomly assigned to participants are LL-BFRt, sham LL-BFRt, and HL-Et. Participants are expected to carry out:

Participants in LL-BFRt will be required to perform LL eccentric training at 30% of their repetition maximum (RM) and 70% of their artery occlusion pressure (AOP). This training will include stairs, single leg squat, and single leg deadlift.

Participants in HL-Et will be required to perform LL eccentric training at 70% of their maximum number of repetitions (RM).

In order to determine whether muscular morphology and the prevention of Patellofemoral Pain Syndrome and ACL injury improve following the interventions and follow-up, researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-08-18
• Study First Submitted QC: 2024-08-20
• Study First Posted: 2024-08-22
• Study Start: 2024-09-20
• Primary Completion: 2024-11-20
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-27
• Last Update Posted: 2025-06-29
• Study Completion: 2025-11-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Being between the ages of 15 and 35
• Play level 1 sports (fight martial arts, basketball, futsal, and soccer) at least twice a week
• Never experienced an Patellofemoral Pain Syndrome or ACL injury before
• Never experienced a grade III sprain or strain
• Consent to participate in the study until its conclusion and provide informed consent.

Exclusion Criteria

• Having a tumor, cancer, vena thromboembolic disease, obesity, diabetes, hypertension, anemia, and renal failure
• Disabilities or those who are disabled.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham Low load-BFRt	Sham Low load-BFRt	10% of the arterial occlusion pressure and 30% of the maximum repetition rate
High load-Eccentric training	High load-Eccentric training	70% of the maximum repetition rate
Low load-BFRt	Low load-BFRt	70% of the arterial occlusion pressure and 30% of the maximum repetition rate

Primary Outcome Measures

Name	Time	Method
Patella position	8 weeks	Using a musculoskeletal ultrasonography, researchers will determine the patella position.
Muscle cross-sectional area	8 weeks	Using a musculoskeletal ultrasonography, researchers will determine the cross-sectional area of vastus medial obliques muscle and peroneus longus muscle.
Vastus medial obliques fiber angle	8 weeks	Using a musculoskeletal ultrasonography, researchers will determine the vastus medial obliques fiber angle.

Secondary Outcome Measures

Name	Time	Method
Incidence of patellofemoral pain syndrome	1 year	Researchers will determine the incidence of patellofemoral pain syndrome with the physical examination of grind test.
Incidence of anterior cruciate ligament injury	1 year	Researchers will determine the incidence of anterior cruciate ligament injury with the physical examination of Lachman's test.

Trial Locations

Locations (1)

Physical therapy laboratory, College of Medicine, Universitas Udayana and ROM Physiotherapy Private Clinic Denpasar; 🇮🇩 Denpasar, Bali, Indonesia